Nhwehwɛmu foforo bi a wɔyɛe wɔ amemene mu nhwehwɛmu mpempem pii a wɔyɛe wɔ owu akyi ho kyerɛ no, awosu mu nkwaadɔm a ɛka nipadua no mu tumi a ɛko tia nyarewa no dwumadi ho no wɔ ɔkwan a ɛnyɛ nea wɔda no adi wɔ nnipa a wɔwɔ ntini ne adwenemyare ahorow bi a autism ka ho no amemene mu.
Wɔ awosu mu nkwaadɔm a ɛko tia nyarewa 1,275 a wɔyɛɛ ho nhwehwɛmu no mu no, 765 (60%) daa adi boro so anaasɛ ɛba fam wɔ mpanyimfo a wɔwɔ nyarewa asia no mu biako amemene mu: autism, adwenemhaw, adwenemhaw, adwenemhaw, Alzheimer yare, anaa Parkinson yare. Nhwehwɛmufo panyin Chunyu Liu, a ɔyɛ adwenemyare ne nneyɛe ho nyansahu ho ɔbenfo wɔ Northern State Medical University a ɛwɔ Syracuse, New York no kae sɛ, ɛsono sɛnea wɔka nsɛm yi wɔ asɛm biara mu, na ɛkyerɛ sɛ emu biara wɔ “nsaano nkyerɛwee” soronko.
Sɛnea Liu kyerɛ no, awosu mu nkwaadɔm a ɛko tia nyarewa a wɔda no adi no betumi ayɛ ɔfe agyiraehyɛde. Saa nipadua no mu tumi a ɛko tia nyarewa a ɛma nipadua no tumi ko tia nyarewa yi, titiriw wɔ awotwaa mu no, ne autism wɔ abusuabɔ, ɛwom sɛ ɔkwan a wɔfa so ba no mu nna hɔ de.
Liu kae sɛ: “M’adwene ne sɛ nipadua no mu tumi a ɛko tia nyarewa no di dwuma titiriw wɔ amemene mu nyarewa mu.” “Ɔyɛ obi a ɔbɔ bɔɔl kɛse.”
Christopher Coe, ɔbenfo a wɔagye no atom wɔ abɔde a nkwa wom ho adwene ho adesua mu wɔ Wisconsin-Madison Sukuupɔn mu, a wamfa ne ho anhyɛ nhwehwɛmu no mu no kae sɛ ɛrentumi nyɛ yiye sɛ wobefi nhwehwɛmu no mu ate ase sɛ ebia nipadua no mu tumi a ɛko tia nyarewa no di dwuma wɔ yare biara a ɛde ba anaasɛ yare no ankasa mu anaa. eyi maa nsakrae baa nipadua no mu tumi a ɛko tia nyarewa no mu. Adwuma.
Liu ne ne kuw no yɛɛ sɛnea nipadua no mu nkwaadɔm a ɛko tia nyarewa 1,275 a wɔda no adi no mu nhwehwɛmu wɔ amemene mu nhwɛsode 2,467 a wɔyɛe wɔ owu akyi mu, a nnipa 103 a wɔwɔ autism ne 1,178 a wɔhwɛ wɔn ka ho. Wonyaa nsɛm fii transcriptome databea abien, ArrayExpress ne Gene Expression Omnibus, ne nhwehwɛmu afoforo a wɔadi kan atintim mu.
Sɛ wɔkyekyem pɛpɛɛpɛ a, sɛnea awosu mu nkwaadɔm 275 da adi wɔ ayarefo a wɔwɔ autism amemene mu no yɛ soronko wɔ nea ɛwɔ kuw a wɔhwɛ so no mu no ho; Alzheimer ayarefo amemene wɔ awosu mu nkwaadɔm 638 a wɔda no adi wɔ ɔkwan soronko so, na ɛno akyi no, adwenemhaw (220), Parkinson (97), adwenemhaw (58), ne adwenemhaw (27) di akyi.
Ná mmarima a wɔwɔ autism amemene no sakra kɛse sen mmea a wɔwɔ autistic, na na ɛsono mmea a wɔahaw no amemene kɛse sen mmarima a wɔwɔ adwenemhaw no de. Tebea horow anan a aka no ankyerɛ nsonsonoe biara wɔ mmarima ne mmea ntam.
Nneɛma a wɔda no adi a ɛbata autism ho no ma yɛkae ntini mu yare te sɛ Alzheimer ne Parkinson sen adwenemyare afoforo. Sɛnea wɔkyerɛ ase no, ɛbɛyɛ sɛ na ntini mu yare nim amemene no nipadua mu nneɛma, te sɛ dopaminergic ntini a ɛyera wɔ Parkinson yare no mu a ɛyɛ su no. Nhwehwɛmufo nnya nkyerɛkyerɛɛ autism su yi mu.
Liu kae sɛ: “Saa [nsɛdi] yi ma yenya akwankyerɛ foforo a ɛsɛ sɛ yɛhwehwɛ mu ara kwa.” “Ebia da bi yɛbɛte pathology ase yiye.”
Wɔtaa sesa awosu mu nkwaadɔm abien, CRH ne TAC1, wɔ saa nyarewa yi mu: Wɔtew CRH so wɔ nyarewa nyinaa mu gye Parkinson yare no nkutoo, na wɔtew TAC1 so wɔ nyarewa nyinaa mu gye adwenemhaw. Awosu abien no nyinaa nya microglia, amemene no mu nkwammoaa a ɛko tia nyarewa no dwumadi.
Coe kae sɛ microglia a wɔma ɛyɛ adwuma a ɛnyɛ nea wɔtaa yɛ no betumi “asɛe ntini mu nkwaadɔm ne synaptogenesis a ɛfata,” na saa ara na asɛe ntini ahorow no dwumadi wɔ tebea horow mu.
Nhwehwɛmu bi a wɔyɛe wɔ afe 2018 mu wɔ amemene mu ntini a wɔde owu akyi no kyerɛe sɛ awosu mu nkwaadɔm a ɛne astrocytes ne synaptic dwumadi wɔ abusuabɔ no da adi pɛpɛɛpɛ wɔ nnipa a wɔwɔ autism, schizophrenia, anaa bipolar disorder mu. Nanso nhwehwɛmu no hui sɛ microglial awosu mu nkwaadɔm no da adi boro so wɔ ayarefo a wɔwɔ autism nkutoo mu.
Michael Benros, nhwehwɛmu no kannifo ne ɔbenfo a ɔkyerɛ abɔde a nkwa wom ne adwenemyare a wɔyɛ no pɛpɛɛpɛ wɔ Copenhagen Sukuupɔn a ɛwɔ Denmark a na ɔmfa ne ho nhyɛ adwuma no mu no kae sɛ ebia nnipa a nipadua no mu tumi a ɛko tia nyarewa no yɛ adwuma kɛse no benya “ntini mu yare.”
Benroth kae sɛ: “Ebia ɛbɛyɛ anigye sɛ yɛbɛbɔ mmɔden ahu akuw nketewa a ebetumi aba yi na yɛde ayaresa pɔtee bi ama wɔn.”
Nhwehwɛmu no hui sɛ nsakrae a ɛba wɔ nkyerɛkyerɛmu mu a wohu wɔ amemene mu ntini nhwɛsode ahorow mu no mu dodow no ara nni dataset ahorow a ɛfa awosu mu nkwaadɔm a wɔda no adi wɔ mogya a efi nnipa a wɔwɔ yare koro no ara mu no mu. Cynthia Schumann, adwenemyare ne nneyɛe ho nyansahu ho ɔbenfo wɔ MIND Asoɛe a ɛwɔ UC Davis a na ɔmfa ne ho nhyɛ nhwehwɛmu no mu no kae sɛ nea wɔahu a “wɔnhwɛ kwan kakra” no kyerɛ hia a ɛho hia sɛ wosua sɛnea amemene no yɛ nhyehyɛe ho ade.
Liu ne ne kuw no reyɛ nkwammoaa mu nhwɛsode ahorow na ama wɔate ase yiye sɛ ebia ɔfe yɛ ade a ɛde amemene mu yare ba anaa.
Wɔdii kan tintim saa asɛm yi wɔ Spectrum, autism nhwehwɛmu amanneɛbɔ wɛbsaet a ɛdi kan no so. Fa asɛm yi ka: https://doi.org/10.53053/UWCJ7407