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So nsu mu nhwehwɛmu a ɛnyɛ den betumi ahu Alzheimer yare no mfiase, na abue kwan ama nhyehyɛe ahorow a wɔde hwehwɛ nnipa pii mu? Akyinnye biara nni ho sɛ Frontiers in Aging Neuroscience nhwehwɛmu foforo no da eyi adi. Nhwehwɛmufo no sɔɔ Alzheimer ayarefo kuw kɛse bi a ɛsono sɛnea emu yɛ den na wɔwɔ apɔwmuden a wɔn adwene mu yɛ den hwɛe de huu nsonsonoe a ɛwɔ nsu mu biomarkers mu.
Wohui sɛ formic acid a ɛwɔ nsu mu no yɛ agyiraehyɛde a ɛyɛ mmerɛw a ɛkyerɛ sɛ obi adwene mu nkate so tew na ebetumi abɔ Alzheimer yare no mfiase ho dawuru. Akwan a ɛwɔ hɔ dedaw a wɔfa so hu Alzheimer yare no bo yɛ den, ɛnyɛ mmerɛw, na ɛnyɛ nea ɛfata sɛ wɔyɛ nhwehwɛmu daa. Eyi kyerɛ sɛ bere a aka akyi dodo sɛ wobenya ayaresa a etu mpɔn nkutoo na wohu ayarefo dodow no ara. Nanso, ebia formic acid a wɔde hwehwɛ nsu mu a ɛnyɛ nea wɔde hyɛ nipadua mu, ne bo nyɛ den, na ɛyɛ mmerɛw no bɛyɛ nea nnuruyɛfo rebisa sɛ wɔmfa nyɛ nhwehwɛmu ntɛm pɛpɛɛpɛ.
Nhoma akyerɛwfo no ka sɛ: “Alzheimer yare yɛ yare a enni sabea a ɛkɔ so na ɛyɛ anifere, a ɛkyerɛ sɛ ebetumi anya nkɔso na atra hɔ mfe pii ansa na adwene mu yare a ɛda adi pefee ada adi.” "Ɔyare no mfiase no ba ansa na adwenemhaw a wontumi nsakra, a ɛyɛ sika kɔkɔɔ mfɛnsere a wɔde wɔn ho gye mu na wɔsa. Enti, ɛfata sɛ wɔyɛ nhwehwɛmu kɛse wɔ Alzheimer yare a edi kan wɔ wɔn a wɔn mfe akɔ anim mu."
Enti, sɛ ntɛm a wɔde wɔn ho bɛhyɛ mu ho hia a, dɛn nti na yenni nhyehyɛe ahorow a wɔyɛ daa de hwehwɛ Alzheimer yare a edi kan no mu? Ɔhaw no wɔ akwan a nnuruyɛfo fa so hwehwɛ yare no mu mprempren. Eyinom bi ne amemene no mu positron emission tomography a ne bo yɛ den na ɛma ayarefo nya mframa a ano yɛ den. Biomarker nhwehwɛmu ahorow nso wɔ hɔ a ebetumi ahu Alzheimer yare, nanso ɛhwehwɛ sɛ wɔtwe mogya a wɔde hyɛ nipadua mu anaasɛ wɔtow akyi berɛmo mu na ama wɔanya amemene mu nsu, a ebia ayarefo retwentwɛn so.
Nanso, nsu mu nhwehwɛmu nyɛ nea wɔde hyɛ nipadua mu na ɛyɛ mmerɛw, na ɛma ɛyɛ nea eye ma nnipadɔm nhwehwɛmu. Ɛwom sɛ nhwehwɛmufo adi kan ahu nsu mu nkwaadɔm a ɛkyerɛ Alzheimer yare no de, nanso emu biara mfata sɛ wobehu yare no mfiase, a ɛkyerɛ sɛ sika kɔkɔɔ mfɛnsere a wɔde sa yare ntɛm no da so ara yɛ nea wontumi nhu.
Nhwehwɛmufo a wɔhyɛ nhwehwɛmu foforo no akyi no adi kan asua aduru bi a wɔfrɛ no formaldehyde ho nhwehwɛmu sɛ ɛyɛ nsu mu biomarker a ɛkyerɛ Alzheimer yare no. Nanso, baabi wɔ hɔ a wobetumi anya nkɔso wɔ yare a wohu ntɛm no mu. Wɔ nhwehwɛmu a etwa to yi mu no, wɔde wɔn adwene sii formate, formaldehyde metabolite so, de hwɛɛ sɛ ɛyɛ adwuma yiye sɛ biomarker anaa.
Nnipa a wɔn dodow yɛ 574 na wɔde wɔn ho hyɛɛ nhwehwɛmu no mu, na na wɔn a wɔde wɔn ho hyɛɛ mu no yɛ atuhoamafo a wɔwɔ apɔwmuden wɔ adwene mu anaasɛ na ɛsono sɛnea yare no kɔ so, efi adwene a ɛkɔ fam wɔ wɔn tirim so kosi yare koraa so. Nhwehwɛmufo no yɛɛ wɔn a wɔde wɔn ho hyɛɛ mu no nsu ne mogya mu nhwehwɛmu na wɔyɛɛ adwene mu nhwehwɛmu.
Nhwehwɛmu no hui sɛ formic acid dodow a ɛwɔ nsu mu no kɔɔ soro kɛse wɔ Alzheimer yare akuw no nyinaa mu na ɛne adwene mu ɔhaw a ɛkɔ fam no wɔ abusuabɔ bere a wɔde toto wɔn a wɔhwɛ wɔn a wɔwɔ apɔwmuden ho, a kuw a wɔn adwene mu yɛ wɔn naa mfiase no ka ho no. Eyi kyerɛ sɛ ebia formic acid bɛyɛ biomarker a ɛyɛ mmerɛw ma Alzheimer yare no mfiase.
Nea ɛyɛ anigye no, bere a nhwehwɛmufo no yɛɛ nsu mu formate dodow mu nhwehwɛmu de kaa Alzheimer mogya mu biomarkers ho no, wohui sɛ wobetumi ahyɛ yare no fã a ɔyarefo bi refa mu no ho nkɔm pɛpɛɛpɛ. Nanso, nhwehwɛmu foforo ho hia na ama wɔate abusuabɔ a ɛda Alzheimer yare ne formic acid ntam no ase.
Nhoma akyerɛwfo no ka sɛ: “Formic acid a wɔde gu nsu mu ada no adi sɛ ɛyɛ mmerɛw yiye sɛ wɔbɛhwehwɛ Alzheimer yare no mu ntɛm.” “Nsu mu biomarker nhwehwɛmu a wɔde hu Alzheimer yare no yɛ nea ɛfata na ɛho ka sua na ɛsɛ sɛ wɔde ka akwahosan ho nhwehwɛmu a wɔyɛ daa ma wɔn a wɔn mfe akɔ anim ho.”
Wang, Y. ne afoforo. (2022) Nhyehyɛeɛ mu nhwehwɛmu a ɛfa urinary formic acid ho sɛ biomarker foforɔ a ɛbɛtumi aba ama Alzheimer yareɛ. Ahye a ɛwɔ onyin ho ntini mu nkwaadɔm ho adesua mu. 10.3389/fnagi.2022.1046066.
Tags: onyin, Alzheimer yare, biomarkers, mogya, amemene, nyarewa a enni sabea, a enni sabea, nnuru, adwenemhaw, nhwehwɛmu, nnuruyɛfo, formaldehyde, ntini mu yare, positron emission tomography, nhwehwɛmu, tomography, nsu mu nhwehwɛmu
Wɔ Pittcon 2023 a ɛwɔ Philadelphia, Pennsylvania no, yebisabisaa Ɔbenfoɔ Joseph Wang a ɔdii nkonim wɔ afe yi Ralph N. Adams Prize wɔ Analytical Chemistry mu no nsɛm faa sɛdeɛ biosensor mfiridwuma tumi yɛ adwuma wɔ mmeaeɛ ahodoɔ ho.
Wɔ saa nsɛmbisa yi mu no, yɛne Mariana Leal, Kuo Kannifoɔ wɔ Owlstone Medical ka ɔhome mu biopsy ne sɛdeɛ ɛbɛtumi ayɛ adwinnadeɛ a mfasoɔ wɔ so de asua biomarkers a wɔde bɛhunu yareɛ ntɛm.
Sɛ yɛn SLAS US 2023 nhwehwɛmu no fã bi no, yɛne Luigi Da Via, GSK Test Development Team Lead susuw daakye lab ne sɛnea ebetumi ayɛ ho.
News-Medical.Net de aduruyɛ ho nsɛm ho dwumadie yi ma wɔ saa nhyehyɛeɛ ne nhyehyɛeɛ yi so. Yɛsrɛ sɛ hyɛ no nsow sɛ wɔayɛ aduruyɛ ho nsɛm a ɛwɔ wɛbsaet yi so no sɛ ɛbɛboa, na ɛnyɛ sɛ ɛbɛsi ɔyarefo no oduruyɛfo/oduruyɛfo abusuabɔ ne aduruyɛ ho afotu a ebia wɔde bɛma no ananmu.